nrg1β1 (R&D Systems)
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nrg1β1
Nrg1β1, supplied by R&D Systems, used in various techniques. Bioz Stars score: 95/100, based on 124 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/recombinant+nrg1%CE%B21/Recombinant+Human+NRG1-beta+1%2FHRG1-beta+1+EGF+Domain+Protein/pmc11983618-158-39-41
Average 95 stars, based on 124 article reviews
Nrg1β1, supplied by R&D Systems, used in various techniques. Bioz Stars score: 95/100, based on 124 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/recombinant+nrg1%CE%B21/Recombinant+Human+NRG1-beta+1%2FHRG1-beta+1+EGF+Domain+Protein/pmc11983618-158-39-41
Average 95 stars, based on 124 article reviews
nrg1β1 - by Bioz Stars,
2026-09
95/100 stars
Images
1) Product Images from "Dynamic regulation of Rgs16 and its correlation with Neuregulin1 expression in acute and chronic nerve injury"
Article Title: Dynamic regulation of Rgs16 and its correlation with Neuregulin1 expression in acute and chronic nerve injury
Journal: Frontiers in Cell and Developmental Biology
doi: 10.3389/fcell.2025.1540453
Figure Legend Snippet: Evaluation of Rgs16 expression in acute and chronic injury and after NRG1β1 stimulation of Schwann cells. (A–C) Quantitative expression analysis of Rgs16 under regenerating and degenerating conditions following traumatic injury to the median nerve in Wistar rats. The relative quantification of Rgs16 was evaluated by qRT-PCR at different time points after injury (d = day post-injury). Regenerating conditions: (A) crush injury; (B) end-to-end repair after transection injury. Degenerating conditions: (C) transection injury. The geometric mean of the housekeeping genes Ankrd27 and Rictor was used to normalize data. The healthy nerves were used as calibrator. The values in the graphs are expressed as the mean ± SEM (n = 3-6 each group). (D) Comparative analysis of Rgs gene expression in rat Schwann cells after chronic constriction injury obtained from single-cell RNA sequencing dataset. The heatmap shows average expression levels of the Rgs gene family for uninjured (Un) versus 3 days post-injury (3d) and 12 days post-injury (12d) conditions. The table below presents adjusted p-values from Wilcoxon and Likelihood-ratio (bimodal) tests for Rgs16 , indicating significant differential expression. (E, F) Normalized counts of RNA-sequencing data of Rgs16 and Nrg1 genes in a model of chronic demyelinating pathology Charcot-Marie-Tooth disease type-1A during development. The values in the graphs are expressed as the mean ± SEM (n = 4 each group). (G) Quantitative expression analysis by qRT-PCR of Rgs16 after 10 nM NRG1β1 stimulation of Schwann cells. Tbp was used as a housekeeping gene to normalize data. Untreated cells were used as calibrator. The values in the graph are expressed as the mean ± SEM (n = 3 each group). (H) Western blot analysis of RGS16 after 10 nM NRG1β1 stimulation of primary cultures of Schwann cells at different time points.
Techniques Used: Expressing, Quantitative Proteomics, Quantitative RT-PCR, Gene Expression, RNA Sequencing, Western Blot
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Incubation:Article Title: Fibroblasts Colonizing Nerve Conduits Express High Levels of Soluble Neuregulin1, a Factor Promoting Schwann Cell Dedifferentiation Article Snippet: .. The epineurium was removed, nerves were cut into small pieces about 1 mm long, then were evenly distributed in a 3 cm diameter Petri dish and were incubated for 24 h in dissociation medium Dulbecco Modified Eagle Medium (DMEM, Gibco, Thermo Fisher Scientific, Waltham, MA, USA) containing 1 g/L glucose, 10% heat-inactivated fetal bovine serum (FBS; Invitrogen, Thermo Fisher Scientific), 100 units/mL penicillin, 0.1 mg/mL streptomycin, 10 μM Forskolin, 63 ng/mL Modification:Article Title: Fibroblasts Colonizing Nerve Conduits Express High Levels of Soluble Neuregulin1, a Factor Promoting Schwann Cell Dedifferentiation Article Snippet: .. The epineurium was removed, nerves were cut into small pieces about 1 mm long, then were evenly distributed in a 3 cm diameter Petri dish and were incubated for 24 h in dissociation medium Dulbecco Modified Eagle Medium (DMEM, Gibco, Thermo Fisher Scientific, Waltham, MA, USA) containing 1 g/L glucose, 10% heat-inactivated fetal bovine serum (FBS; Invitrogen, Thermo Fisher Scientific), 100 units/mL penicillin, 0.1 mg/mL streptomycin, 10 μM Forskolin, 63 ng/mL Recombinant:Article Title: Fibroblasts Colonizing Nerve Conduits Express High Levels of Soluble Neuregulin1, a Factor Promoting Schwann Cell Dedifferentiation Article Snippet: .. The epineurium was removed, nerves were cut into small pieces about 1 mm long, then were evenly distributed in a 3 cm diameter Petri dish and were incubated for 24 h in dissociation medium Dulbecco Modified Eagle Medium (DMEM, Gibco, Thermo Fisher Scientific, Waltham, MA, USA) containing 1 g/L glucose, 10% heat-inactivated fetal bovine serum (FBS; Invitrogen, Thermo Fisher Scientific), 100 units/mL penicillin, 0.1 mg/mL streptomycin, 10 μM Forskolin, 63 ng/mL |